Marco DeRuiter started his research on the embryonic development of the cardiovascular system in 1989. After 20 years of experience in research and teaching, he accepted a full professorship in Clinical and Experimental Anatomy at the Leiden University Medical Center, The Netherlands in 2010. In this position, he is responsible for all current (post)graduate teaching activities and the development of new strategies for technology enhanced learning. His main research projects focus on the development of the cardiovascular outflow tract in human and animal models. In various (inter)national consortia he supervises projects on the origin of bicuspid aortic valve formation with the intriguing associated problem of aorta dilatation using genetic cell lineage tracing techniques in combination with state-of-the-art molecular biological techniques. In addition, Marco is a scientific consultant in surgical anatomy. In this function, he is involved in many research studies to elaborate new techniques to reduce surgically induced morbidity.