Stephen Large was appointed to Royal Papworth Hospital in 1989 with a specialist interest in surgery for ventricular tachycardia. His early interest in medical student education led to a Cambridge University appointment as Associate Lecturer in the Department of Medicine and on to become clinical sub-dean for cardiac and thoracic services. He was awarded the diploma of Physician as Educator- RCP by the Royal College of Physicians in 2001 after becoming a fellow five years earlier. He ran the heart transplant service from appointment to the end of 2008 developing the national mechanical heart assist programme in 2001 through his particular interest in the failing human heart.
His research interest lies in this area and his team are pursuing the possibilities of expanding the human donor heart pool through collaboration with the clinical transplant team in Cambridge, Stanford University, California and the Canadian Research Centre in Winnipeg. An additional fascination with management led him to achieve an MBA through the Open University in 2000 and to chair the Cardiac Directorate for five years until 2007. He now represents the speciality on the Interventional Advisory Committee of NICE, the HTA Interventional committee and is lead investigator of HTA observational study ETTAA (5 years from July 2013 value £1.7 million).